Glutathione

Supporting oxidative balance and cellular function

Glutathione is one of the body's most important endogenous antioxidants, naturally present in cells and involved in essential mechanisms of cellular protection, detoxification and oxidative balance.

At the Maison Longévité clinic, the intravenous administration of glutathione is included in medical programs oriented towards supporting metabolic health, mitochondrial function and the processes associated with healthy longevity.

Glutathione is studied for its role in:

• neutralizing oxidative stress
• cellular protection against free radicals
• cellular detoxification processes
• mitochondrial function
• supporting the cellular redox balance

Glutathione levels can be influenced by advancing age, chronic stress, inflammation, metabolic overload, toxic exposures or certain conditions.

Who can it be for?

The intravenous administration of glutathione may be included, in certain medical contexts, in programs dedicated to:

• supporting antioxidant mechanisms
• recovery after periods of oxidative stress or overload
• supporting hepatic and metabolic function
• healthy aging and slow-aging programs
• supporting cellular recovery and resilience
• people with non-alcoholic fatty liver disease (NAFLD), within an integrated medical approach
• people exposed to increased oxidative stress associated with lifestyle, chronic stress or metabolic overload

Eligibility and the administration protocol are established individually, following a medical assessment.

The Maison Longévité approach

At the Maison Longévité clinic, the administration of glutathione is integrated into a broader medical strategy, which may include:

• sleep optimization
• personalized nutrition
• adapted physical activity
• stress management
• supporting metabolic and hepatic health

Every recommendation is made in the context of the clinical assessment and integrated into a medical plan adapted to the needs of each patient.

In certain situations, the assessment may also include the measurement of markers associated with oxidative stress and the antioxidant systems, including reduced glutathione (GSH) or glutathione peroxidase.

Possible reactions during administration

Some people may temporarily experience:

• nausea
• dizziness
• headache
• a sensation of heat
• discomfort at the administration site

These manifestations are usually transient.

Contraindications and precautions

Contraindications

• pregnancy and breastfeeding
• acute infections or febrile states
• hypersensitivity to the components used
• severe hepatic or renal failure

Precautions

• a history of bronchial asthma or bronchospasm
• sensitivity to sulfur-containing compounds

Administration is carried out exclusively following a medical assessment and the establishment of therapeutic eligibility.

What does the scientific literature say?

Glutathione is a central element of the endogenous antioxidant systems and is intensively studied for its role in cellular protection, mitochondrial function and oxidative balance.

Current literature explores the relationship between oxidative stress, cellular metabolism and various processes associated with aging and metabolic health, including in the context of non-alcoholic fatty liver disease (NAFLD), but the clinical response may vary individually.

Scientific references

• Wu G et al. Glutathione metabolism and its implications for health. J Nutr. 2004.
• Forman HJ et al. Glutathione: overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 2009.
• Ballatori N et al. Glutathione dysregulation and the etiology and progression of human diseases. Biol Chem. 2009.
• Lu SC. Glutathione synthesis. Biochim Biophys Acta. 2013.
• Sekhar RV et al. Glutathione synthesis is diminished in patients with uncontrolled diabetes and restored by dietary supplementation with cysteine and glycine. Diabetes Care. 2011.
• Honda Y et al. Glutathione improves nonalcoholic fatty liver disease in patients with nonalcoholic fatty liver disease. BMC Gastroenterology. 2017.